Thermo Fisher Scientific BAG4 Polyclonal Antibody
BAG4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA에 적합하며 Human, Mouse, Rat 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 안정적 저장 가능.
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- PA5109441
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human BAG4 (NP_001191807.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854852 |
Product Specific Information
Immunogen sequence:
MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ SLNSYTNGAY
Target Information
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that interacts with various apoptosis and growth-related proteins such as BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors, and members of the Hsp70 family.
This protein contains a BAG domain near the C-terminus, which can bind and inhibit the chaperone activity of Hsc70/Hsp70. It associates with the death domains of TNF-R1 and DR3, negatively regulating downstream cell death signaling. The regulatory role of this protein in apoptosis has been demonstrated in epithelial cells that undergo apoptosis upon loss of integrin-mediated matrix contacts.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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