Thermo Fisher Scientific UFD1 Polyclonal Antibody
Thermo Fisher Scientific의 UFD1 Polyclonal Antibody는 인간 UFD1 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- A301876A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 257 and 307 of Human ubiquitin fusion degradation 1 (UFD1L, UniProt ID: Q92890-2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse and Rat
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, leading to their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
The UFD1 protein, originally identified in S. cerevisiae, has a human homolog (UFD1L) that modulates degradation of Ub-fusions with substitutions at the Gly76 residue. Mutations in the UFD1 gene are linked to CATCH22 syndrome, which involves cardiac defects, cleft palate, and hypocalcemia, suggesting a role in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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