Thermo Fisher Scientific RAB3c Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-772 detects Rab3C from mouse and rat tissues and cells.
It has been successfully used in Western blot and immunoprecipitation procedures.
By Western blot, this antibody detects a 22 kDa protein representing Rab3C from AtT20 cell extract.
The immunogen is a synthetic peptide corresponding to residues M(9) A S A Q D A R F G Q K D S S D Q N(26) C of rat RAB3C.
This immunizing peptide (Cat. # PEP-106) is available for use in neutralization and control experiments.

Target Information

Rab proteins are low-molecular-weight GTP-binding proteins forming the largest branch of the Ras superfamily of GTPases.
Located on the cytoplasmic face of organelles and vesicles, Rab proteins are involved in intracellular membrane fusion reactions.
Three membrane proteins—synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin—form the core of a ubiquitous membrane fusion machine that interacts with soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP.
Rab proteins, in coordination with the core fusion machinery and Munc-18, help mediate vesicle docking and fusion.
Over 40 Rab proteins have been described in mammals. Rab3C is found in brain, adrenal gland, and pituitary.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.