
Thermo Fisher Scientific CLN3 Polyclonal Antibody
인간 CLN3 단백질을 인식하는 Rabbit Polyclonal 항체입니다. IHC(P)에서 1:200~1:500 희석으로 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 용액 형태로 제공됩니다. Batten 병 연구 등 CLN3 관련 연구에 적합합니다.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CLN3. Recombinant protein control fragment (Product # RP-104248) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639893 |
Product Specific Information
Immunogen sequence:
EEEAESAARQ PLIRTEAPES KPGSSSSLSL RERWTVF
Sequence identity with orthologs:
- Mouse: 78%
- Rat: 73%
Target Information
CLN3 is a highly glycosylated, hydrophobic, 438-amino acid protein with six transmembrane domains. It localizes to the lysosomal membrane and plays a key role in lysosomal function. CLN3 may act as a chaperone involved in the folding and unfolding of other proteins, such as subunit C of the ATP synthase complex.
Mutations in the CLN3 gene cause Batten disease, a recessively inherited neurodegenerative disorder characterized by lysosomal accumulation of hydrophobic material, mainly ATP synthase subunit C. Batten disease is the most common form of neuronal ceroid lipofuscinoses (NCLs), presenting with progressive vision loss, seizures, and psychomotor disturbances.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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