Thermo Fisher Scientific RUNX1/RUNX1T1 Polyclonal Antibody
RUNX1/RUNX1T1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot, ELISA, IP, ChIP 등 다양한 응용에 사용 가능하며, 비결합(Unconjugated) 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| ELISA | 1:500 | - |
| Immunoprecipitation (IP) | - | 1 publication |
| ChIP assay (ChIP) | 4 µL | 1 publication |
| ChIP-sequencing (ChIP-Seq) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to human AML1-ETO fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C or -80°C (preferred) |
| Shipping Conditions | Wet ice |
| RRID | AB_2608182 |
Target Information
AML1/Runx1 binds DNA as a monomer and through the Runt domain. DNA binding is increased by heterodimerization with CBFB. Isoform AML1L can neither bind DNA nor heterodimerize and interferes with the transactivation activity of AML1/Runx1.
CBF binds to the core site, 5′-PYGPYGGT-3′, of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T cell receptor enhancers, LCK, IL3, and GMCSF promoters.
The alpha subunit binds DNA and plays a role in normal hematopoiesis. AML1/Runx1 is expressed in all tissues except brain and heart, with highest expression in thymus, bone marrow, and peripheral blood.
Defects in AML1/Runx1 cause familial platelet disorder with associated myeloid malignancy, an autosomal dominant disease characterized by platelet defects and a predisposition to acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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