Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7437)
STING1/TMEM173 단백질을 인식하는 Mouse monoclonal 항체. Western blot 및 IHC(P), IHC(PFA) 적용 가능. 단백질 A/G로 정제된 액상 항체로, PBS(pH 7.4) buffer에 보존제 없이 제공. 선천면역 신호전달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STING1/7437 |
| Immunogen | Recombinant fragment (aa 190–290) of human TMEM173 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Target Information
STING is a 379-amino-acid signaling protein that plays a crucial role in innate immune signaling. It activates both NF-κB and IRF3 transcription pathways to induce type I interferon (IFN-α and IFN-β) expression, establishing a strong antiviral state. STING may function as a translocon influencing interferon induction and is involved in apoptotic signal transduction via MHC-II association. It helps detect intracellular viral RNA and B-form DNA and mediates death signaling through ERK pathway activation. STING is localized in the endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane and is ubiquitously expressed across most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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