Thermo Fisher Scientific E-cadherin Recombinant Rabbit Monoclonal Antibody (5H6L18)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates ~25 kDa light chain and ~50 kDa heavy chain bands.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems, developed by cloning specific antibody DNA sequences from immunoreactive rabbits.
• Advantages include:
  • Better specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulations
  • Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

Target Information

E-Cadherin (epithelial cadherin) is a classical cadherin from the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein with five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the E-cadherin gene (CDH1, chromosome 16) are associated with various cancers including gastric, breast, colorectal, thyroid, and ovarian cancer. Loss of E-cadherin function contributes to cancer progression by increasing proliferation, invasion, and metastasis.
E-cadherin is essential for maintaining tissue architecture and integrity, mediating bacterial adhesion to mammalian cells, and enabling internalization through its cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.