Thermo Fisher Scientific SETD8 Polyclonal Antibody
SETD8 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, ICC/IF, ELISA에 적용 가능. 인간, 마우스, 랫트 반응성. 액상 형태로 보관하며 세포 증식 및 염색질 구조 연구에 적합.
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Thermo Fisher Scientific SETD8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human KMT5A/KMT5A/SETD8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806454 |
Product Specific Information
- Positive Samples: 293T
- Cellular Location: Chromosome, Nucleus
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4. This modification is enriched during mitosis and serves as a marker for epigenetic transcriptional repression. SETD8 functions mainly in euchromatin regions, playing a key role in silencing euchromatic genes. It is required for cell proliferation, contributing to proper higher-order DNA structure during mitosis, chromosome condensation, and cytokinesis. Nucleosomes are preferred substrates over free histones.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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