Thermo Fisher Scientific ERCC1 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 ERCC1 폴리클로날 항체로 DNA 수선 관련 연구에 적합함. Western blot 및 ELISA에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/glycerol 버퍼에 보존. 세포 내 위치는 세포질 및 핵.
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Thermo Fisher Scientific ERCC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–323 of human ERCC1 (NP_973730.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.95 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806460 |
Product Specific Information
- Positive Samples: Raji, MCF-7, PC-3, HepG2, HeLa, Mouse liver, Mouse brain
- Cellular Location: Cytoplasm, Nucleus
Immunogen sequence:
MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVAKPLF RSTQSLPTVD TSAQAAPQTY AEYAISQPLE GAGATCPTGS EPLAGETPNQ ALKPGAKSNS IIVSPRQRGN PVLKFVRNVP WEFGDVIPDY VLGQSTCALF LSLRYHNLHP DYIHGRLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLILAW SPEEAGRYLE TYKAYEQKPA DLLMEKLEQD FVSRVTECLT TVKSVNKTDS QTLLTTFGSL EQLIAASRED LALCPGLGPQ KVRALGKNPR SWGKERAPNK HNLRPQSFKV KKEPKTRHSG FRL
Target Information
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5′-incision during DNA repair. In conjunction with SLX4, it performs the first step in the repair of interstrand cross-links (ICL). ERCC1 participates in processing DNA structures that can lead to cytokinesis failure and is required for homology-directed repair (HDR) of DNA double-strand breaks with SLX4.
(Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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