Thermo Fisher Scientific HP1 alpha Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-C133)
HP1 alpha(CBX5) 단백질을 특이적으로 인식하는 재조합 토끼 단클론 항체. Western blot, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능. HEK293 세포에서 발현된 IgG kappa 형식의 항체로, Protein A로 정제됨. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 0.003 µg/mL | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Flow Cytometry (Flow) | 1:100 | |
| ELISA | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent | |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C133 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing CBX5 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074771 |
Product Specific Information
Specificity: Recognizes CBX5 (Chromobox protein homolog 5), binding to a folded domain (amino acids 18–75).
CBX5 is a heterochromatin component that binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression.
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, mediating gene silencing.
Mammalian methyltransferases that methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, which act as adaptor molecules involved in gene silencing and chromatin structure regulation.
The HP1 chromodomain specifically recognizes the methylated lysine-9 epitope on histone H3.
In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-primary mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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