Thermo Fisher Scientific GALE Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: AEKVLVTGGA GYIGSHTVLE LLEAGYLPVV IDNFHNAFRG GGSLPESLRR
• Sequence homology:
  • Cow: 93%
  • Dog: 86%
  • Guinea Pig: 86%
  • Human: 100%
  • Mouse: 91%
  • Pig: 91%
  • Rabbit: 92%
  • Rat: 91%

Target Information

This gene encodes UDP-galactose-4-epimerase, which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has an important metabolic consequence: mutant cells (or individuals) depend on exogenous galactose and N-acetylgalactosamine for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia (galactosemia type 3), characterized by liver damage, early-onset cataracts, deafness, and mental retardation, with symptoms ranging from mild (peripheral form) to severe (generalized form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.