Thermo Fisher Scientific GALE Polyclonal Antibody
Rabbit polyclonal antibody against human GALE protein. Validated for Western blot applications. Supplied as a liquid, unconjugated form with 0.5 mg/mL concentration. Suitable for research use in studying galactose metabolism and GALE-related pathways.
- 카탈로그번호
- PA544158
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human GALE (aa 2–51) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607859 |
Product Specific Information
- Peptide sequence: AEKVLVTGGA GYIGSHTVLE LLEAGYLPVV IDNFHNAFRG GGSLPESLRR
- Sequence homology:
- Cow: 93%
- Dog: 86%
- Guinea Pig: 86%
- Human: 100%
- Mouse: 91%
- Pig: 91%
- Rabbit: 92%
- Rat: 91%
Target Information
This gene encodes UDP-galactose-4-epimerase, which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has an important metabolic consequence: mutant cells (or individuals) depend on exogenous galactose and N-acetylgalactosamine for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia (galactosemia type 3), characterized by liver damage, early-onset cataracts, deafness, and mental retardation, with symptoms ranging from mild (peripheral form) to severe (generalized form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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