Thermo Fisher Scientific PTPRC Monoclonal Antibody (OTI2H1), TrueMAB
Thermo Fisher Scientific의 PTPRC (CD45) 단클론 항체 OTI2H1은 인간 시료에 반응하며 Western blot, IHC, Flow cytometry에 적합합니다. 동결건조 형태로 제공되며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:8000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H1 |
| Immunogen | Full length human recombinant protein of human PTPRC produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, constituting about 10% of lymphocyte surface proteins.
It is absent in non-hematopoietic cells and tissues. CD45 is essential for lymphocyte development and antigen signaling, acting as a regulator of Src-family kinases.
Multiple isoforms of CD45 arise from alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic domains.
CD45RA, one of its isoforms, shows restricted expression among lymphoid subtypes. The protein regulates T- and B-cell receptor signaling, modulates cytokine receptor signaling via JAK kinases, and influences integrin-mediated pathways and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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