Thermo Fisher Scientific CD122 Monoclonal Antibody (TU27)
CD122(IL-2Rβ)을 인식하는 Mouse monoclonal antibody로, Flow Cytometry, Immunoprecipitation, Functional Assay에 사용 가능. Human 시료 반응성, 단클론 IgG1, kappa 타입. PBS(pH 7.4) 용액, 보존제 없음, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TU27 |
| Immunogen | TL-Mor cell line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912985 |
Product Specific Information
This antibody recognizes an extracellular epitope of CD122 (IL-2R beta), a 70–75 kDa type I transmembrane glycoprotein constitutively expressed by NK cells and a subset of T cells, and upregulated upon activation.
Functional application: Blocking
Target Information
CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses and is primarily expressed in the hematopoietic system.
It exists in three forms:
- Low affinity form: alpha subunit monomer, not involved in signal transduction
- Intermediate affinity form: alpha/beta heterodimer
- High affinity form: alpha/beta/gamma heterotrimer
Both intermediate and high affinity forms are involved in receptor-mediated endocytosis and mitogenic signal transduction.
The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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