Thermo Fisher Scientific CD81 Monoclonal Antibody (M38)

Thermo Fisher Scientific CD81 Monoclonal Antibody (M38)

Applications and Tested Dilutions

Product Specifications

Additional Formats

• Alexa Fluor 488
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD81, a 25 kDa member of the tetraspanin family expressed on the majority of cells.
Positive control: Jurkat cells under non-reducing conditions.
Functional application: In human MOLT-4 T-cell line, antibody M38 inhibits syncytium formation induced by coculture with HTLV-1–positive human T-cell lines.

Target Information

CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, expressed on nearly all nucleated cells, particularly germinal center B cells.
It forms complexes with other tetraspanin proteins, integrins, coreceptors, and MHC molecules, influencing adhesion, morphology, activation, proliferation, and differentiation of B and T cells.
In muscle cells, CD81 promotes cell fusion and myotube maintenance and serves as a receptor for hepatitis C virus.
Antibodies to CD81 exhibit anti-proliferative effects on various lymphoid cell lines, especially large cell lymphomas.
CD81 is localized in a tumor-suppressor gene region and considered a candidate gene for malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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