Thermo Fisher Scientific Phospho-AGO2 (Tyr393) Polyclonal Antibody
Phospho-AGO2 (Tyr393) 특이적 폴리클로날 항체로 인간, 마우스, 랫트에 반응합니다. Western blot 및 ICC/IF에 적합하며, RNA silencing 경로 연구에 활용됩니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-Ago2 (Tyr-393) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding tyrosine 393 in human Ago2. Highly conserved in mouse, rat, chick, and fish Ago2. Conserved in Ago1 and Ago4, but not in Ago3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942876 |
Product Specific Information
This antibody was cross-absorbed to unphospho-Ago2 (Tyr-393) before affinity purification using phospho-Ago2 (Tyr-393) peptide. It detects a 97 kDa protein corresponding to phosphorylated Ago2 on SDS-PAGE immunoblots of human A431 cells treated with EGF. This reactivity disappears after lambda phosphatase dephosphorylation.
Target Information
Ago proteins are broadly expressed in somatic cells and associate with miRNAs, acting as key mediators in RNA silencing pathways. Among them, Ago2 uniquely possesses endonucleolytic “Slicer” activity, enabling miRNA-directed cleavage of target mRNA when perfect base-pairing occurs. With partial complementarity, Ago2 represses translation instead of cleavage. Ago2 plays crucial roles in RNA interference, translation repression, and heterochromatinization. As part of the RISC complex, AGO2 initiates mRNA degradation guided by siRNAs or miRNAs and also regulates miRNA maturation. Overexpression of Ago2 is linked to tumor growth and cancer prognosis. Mouse gene disruption studies confirm its essential role in embryonic development and B-lymphoid and erythroid regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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