Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (rDHTR/8818)
안드로겐 수용체(AR)를 표적하는 Thermo Fisher의 재조합 토끼 단일클론 항체. IHC(P) 검증 완료, 인간 시료 반응. 핵 내 단백질 위치 확인에 적합하며, 남성 생식기관 관련 연구 및 암 연구용으로 활용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rDHTR/8818 |
| Immunogen | Recombinant full-length human AR protein (UniProt ID: P10275-1, amino acids 1–920) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Breast, LNCap cells, human testis, prostate, or prostate carcinoma
- Cellular Location: Nucleus
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is essential for the development and function of male reproductive organs such as the prostate and epididymis, and also influences nonreproductive organs including muscle, hair follicles, and brain. It functions as a phosphoprotein regulating MAP kinase pathways. Dysregulation or mutation of AR is associated with prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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