Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Monoclonal Antibody (AR441)
Androgen Receptor(AR) 단백질을 검출하는 Mouse monoclonal antibody(클론 AR441). IHC, ICC/IF, Flow Cytometry에 적합하며 Human 시료에 반응. Protein A/G 정제, 4°C 보관, 연구용 전용 시약.
- 카탈로그번호
- 367-MSM1-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Monoclonal Antibody (AR441)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AR441 |
| Immunogen | A synthetic peptide, aa 302–318 (STEDTAEYSPFKGGYTK) of human AR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor (~90 kDa) contains three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.
AR is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling is essential for the development and function of male reproductive organs (prostate, epididymis) and also influences nonreproductive tissues such as muscle, hair follicles, and brain.
As a phosphoprotein, AR regulates the MAP kinase pathway, and MEK1/2 inhibition alters its phosphorylation state.
Dysregulation of AR signaling is associated with prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene can lead to complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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