Thermo Fisher Scientific MC4 Receptor (extracellular) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

MC4R is expressed primarily in the brain. Unlike other melanocortin receptors, MC4R is not expressed in adrenal cortex or melanocytes.
G-protein Coupled Receptors (GPCRs) form one of the largest signaling molecule families, sharing a seven-transmembrane helical structure and existing in active/inactive forms.
Activation occurs through ligand-induced conformational changes, leading to G-protein signaling and downstream effects.
GPCR regulation and “turn-off” mechanisms are key to understanding cellular physiology and pharmacological development.
Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough), representing major therapeutic markets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.