Thermo Fisher Scientific HFE2 Polyclonal Antibody
HFE2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot과 면역세포염색에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 철 대사 연구 및 juvenile hemochromatosis 관련 연구에 적합합니다.
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Thermo Fisher Scientific HFE2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human RGM-C isoform a (Gln36–Asp400) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607143 |
Product Specific Information
- In direct ELISAs, approximately 10% cross-reactivity with recombinant human RGM-B is observed and less than 5% with rhRGM-A.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
HFE2 is involved in iron metabolism and may participate in the signaling pathway that activates hepcidin or modulate its expression. It might serve as the cellular receptor for hepcidin.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Defects in HFE2 cause hemochromatosis type 2A (juvenile hemochromatosis), an early-onset autosomal recessive disorder characterized by severe iron overload, hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis, and cardiomyopathy, typically before age 30.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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