Thermo Fisher Scientific HFE2 Polyclonal Antibody

Thermo Fisher Scientific HFE2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 10% cross-reactivity with recombinant human RGM-B is observed and less than 5% with rhRGM-A.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

HFE2 is involved in iron metabolism and may participate in the signaling pathway that activates hepcidin or modulate its expression. It might serve as the cellular receptor for hepcidin.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Defects in HFE2 cause hemochromatosis type 2A (juvenile hemochromatosis), an early-onset autosomal recessive disorder characterized by severe iron overload, hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis, and cardiomyopathy, typically before age 30.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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