Thermo Fisher Scientific NOX2 Recombinant Rabbit Monoclonal Antibody (ARC0181)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

View 1 publication 1 publication

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0181

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NOX2/gp91phox (P04839) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NOX2,uniProtId:P04839-1,ncbiNodeId:9606,antigenRange:100-200,antigenLength:570,antigenImageFileName:MA5-35348_NOX2_P04839-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35348_NOX2_P04839-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849249

Product Specific Information

Immunogen sequence: FHKMVAWMIA LHSAIHTIAH LFNVEWCVNA RVNNSDPYSV ALSELGDRQN ESYLNFARKR IKNPEGGLYL AVTLLAGITG VVITLCLILI ITSSTKTIRR S

Target Information

Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase complex expresses in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells. It includes a membrane bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Mox1 and gp91 contain identical C-terminal sequence identity, yet possess distinct expression patterns. gp91-phox expresses in eosinophils, neutrophils, monocytes, and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.