
Thermo Fisher Scientific MLH1 Recombinant Rabbit Monoclonal Antibody (BLR112H)
MLH1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합. 인간 시료 반응성, 고순도 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 6 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR112H |
| Immunogen | Peptide representing a region between residue 450 and 500 of Human DNA mismatch repair protein MLH1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
Target Information
MLH1 is a DNA mismatch repair protein essential for maintaining genetic integrity. Defects in mismatch repair pathways are linked to microsatellite instability (MSI) and human carcinogenesis. Mutations in mismatch repair genes, including MLH1, are associated with hereditary nonpolyposis colon cancer (HNPC). MSH2 is involved in recognizing mismatched nucleotides, and MLH1 forms a heterodimer with PMSH to facilitate subsequent repair steps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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