Thermo Fisher Scientific p53 Monoclonal Antibody (BD53-12)

Thermo Fisher Scientific p53 Monoclonal Antibody (BD53-12)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-7629 detects p53 from human, rat, and mouse samples.
It has been successfully used in ELISA, fluorescent microscopy, flow cytometry, immunoprecipitation, and immunohistochemistry (frozen) procedures.
The MA1-7629 immunogen is a p53 protein.

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress.
It mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides.
p53 activates transcription of specific genes such as p21waf1, leading to G1 or G2/M arrest.
Its structure includes:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerisation domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is key for activation and stabilization.
Phosphorylation at Ser392 is associated with human tumor formation.
p53 plays a critical role in preventing proliferation of damaged cells and acts as an anticancer agent.
It is linked to aging, oxidative stress, and cognitive processes such as learning and memory.
Mutations in p53 are common in human cancers and lead to loss of tumor suppressor function.
Alterations of the TP53 gene occur as somatic or germline mutations, including Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.