Thermo Fisher Scientific CD16 Monoclonal Antibody (ASH 1975)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 4 publications 4 publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

-

Immunocytochemistry (ICC/IF)

-

View 2 publications 2 publications

Flow Cytometry (Flow)

Assay-dependent

-

ELISA (ELISA)

1:500

-

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

ASH 1975

Immunogen

CD16, Human white blood cell fraction if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD16,uniProtId:P08637-1,ncbiNodeId:9606,antigenRange:1-254,antigenLength:254,antigenImageFileName:MA1-7633_CD16_P08637-1_House_mouse.svg,antigenImageFileNamePDP:MA1-7633_CD16_P08637-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:CD16,uniProtId:O75015-1,ncbiNodeId:9606,antigenRange:1-233,antigenLength:233,antigenImageFileName:MA1-7633_CD16_O75015-1_House_mouse.svg,antigenImageFileNamePDP:MA1-7633_CD16_O75015-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.2

Contains

0.01% sodium azide

Storage conditions

4°C short term, -80°C long term

RRID

AB_2103889

Product Specific Information

MA1-7633 detects CD16 from human samples and CD16-2 from mouse and rat.

MA1-7633 has been successfully used in ELISA, IF, flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections) procedures.

The MA1-7633 immunogen is a CD16 protein.

Store at 4ºC short term. For extended storage, store at -80ºC.

Target Information

CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from the circulation, as well as other functions such as cellular mediated cytotoxicity and enhancement of virus infections. This gene, FCGR3A, shares a high degree of similarity with another nearby gene, FCGR3B, located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been associated with immunodeficiency 20 and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.