Thermo Fisher Scientific CD150 Monoclonal Antibody (IPO-3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• MA1-7626 detects SLAM from human samples.
• Validated for use in ELISA and flow cytometry applications.
• Immunogen: activated B cell line.
• Recommended storage: 4°C for short term, -80°C for long term.

Target Information

CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation.
SLAM is expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and some B cells, and is rapidly induced on naive T cells after activation.
Activated B cells express membrane-bound, soluble, and cytoplasmic isoforms of SLAM.
SLAM-SLAM homophilic interactions enhance B cell activation and differentiation.
The extracellular domain of CD150 serves as a receptor for the measles virus and acts as a co-activator on T and B cells.
CD150 interacts with SH2D1A and PTPN11 via its cytoplasmic domain.
Mutations in the CD150 gene may be associated with X-linked lymphoproliferative disease (XLP).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.