Thermo Fisher Scientific CD150 Monoclonal Antibody (IPO-3)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1:750

-

ELISA (ELISA)

1:750

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

IPO-3

Immunogen

Activated B cell line. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD150,uniProtId:Q13291-1,ncbiNodeId:9606,antigenRange:1-335,antigenLength:335,antigenImageFileName:MA1-7626_CD150_Q13291-1_House_mouse.svg,antigenImageFileNamePDP:MA1-7626_CD150_Q13291-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

no preservative

Storage conditions

4°C short term, -80°C long term

RRID

AB_1087314

Product Specific Information

MA1-7626 detects SLAM from human samples.

MA1-7626 has been successfully used in ELISA and flow cytometry procedures.

The MA1-7626 immunogen is an activated B cell line.

Store at 4ºC short term. For long term storage, store at -80ºC.

Target Information

CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.