Thermo Fisher Scientific Phospho-TAK1 (Thr184, Thr187) Polyclonal Antibody
TAK1 단백질의 Thr184/187 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr184/187 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in Wnt, BMP, activin, thyroid hormone, osmotic stress, and endothelin signaling. TAK1 regulates wound healing through activation of von Hippel-Lindau tumor suppressor expression and represses PDGF-B, integrin β1, and β5. It is essential for IKK activation in IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways. Activation involves TAB2/3-mediated ubiquitination and TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, leading to IKK-β phosphorylation. TAK1 also represses human telomerase reverse transcriptase, suggesting a role in cell lifespan regulation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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