Thermo Fisher Scientific ECSIT Polyclonal Antibody
ECSIT 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 IHC에 적합하며, 1 mg/mL 농도의 액상 형태입니다. NF-κB 및 TLR 신호 경로 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 14 amino acids near the C-terminus of human ECSIT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153110 |
Product Specific Information
- Suggested positive control: human heart tissue lysate
- PA5-20082 can be used with blocking peptide PEP-0200
Target Information
Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88 to kinases like IRAK and intermediates such as TRAF6.
ECSIT (Evolutionarily Conserved Signaling Intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TRAF6 in the TLR pathway. It is also required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, suggesting cross-talk between TLR/IL-B and Bmp signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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