Thermo Fisher Scientific UBC13 Polyclonal Antibody
UBC13 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 형태로, PBS 및 sodium azide 포함. DNA 손상 복구 연구 등 다양한 세포생물학 연구에 적합.
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Thermo Fisher Scientific UBC13 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 15 amino acids near the C-terminus of human UBC13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151870 |
Product Specific Information
- Suggested positive control: human small intestine tissue lysate
- PA5-20080 can be used with blocking peptide PEP-0198
Target Information
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains.
This type of polyubiquitination does not lead to protein degradation by the proteasome.
Mediates transcriptional activation of target genes and plays a role in cell cycle control, differentiation, and error-free DNA repair.
Acts together with E3 ligases (HLTF, SHPRH, RNF5) in Lys-63-linked polyubiquitination processes related to DNA repair and protein regulation.
Promotes TRIM5 capsid-specific restriction activity and activates MAP3K7/TAK1 complex leading to NF-kappa-B and MAPK-responsive inflammatory gene expression.
Together with RNF135 and UB2V1, catalyzes viral RNA-dependent Lys-63-linked polyubiquitination of RIG-I/DDX58 to activate interferon beta production.
UBE2V1-UBE2N with TRAF3IP2 E3 ubiquitin ligase mediates Lys-63-linked polyubiquitination of TRAF6 in IL17A signaling pathways.
(Source: Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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