Thermo Fisher Scientific Btk Polyclonal Antibody
Bruton tyrosine kinase(BTK)를 인식하는 Rabbit Polyclonal Antibody로 Western Blot, IHC, ICC, ELISA에 사용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 시약으로 2-8°C 보관. 연구용 전용 제품.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | - |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| ELISA | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to 16 amino acids near the amino-terminus of human BTK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153734 |
Product Specific Information
- Suggested positive control: U937 cell lysate
- PA5-20085 can be used with blocking peptide PEP-0203.
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which are essential for innate and adaptive immunity. BTK also interacts with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting its role in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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