Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• Publications: View 2 publications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:200
• Publications: View 1 publication

Product Specifications

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain and activates enzymatic activity.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
The enzyme’s involvement in catecholamine synthesis suggests its association with neuropathogenic and cardiovascular diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various heart disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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