Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Tyrosine Hydroxylase에 특이적인 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트에 반응합니다. Western blot 및 Immunocytochemistry에 적합하며 고순도 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C 보관, 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 2 publications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:200
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the amino-terminal sequence of human tyrosine hydroxylase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 581 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 50% glycerol, 0.15M NaCl, 100 µg/mL BSA |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979653 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain and activates enzymatic activity.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
The enzyme’s involvement in catecholamine synthesis suggests its association with neuropathogenic and cardiovascular diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various heart disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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