Thermo Fisher Scientific H3K18ac Polyclonal Antibody
H3K18ac 폴리클로날 항체로, 인간·마우스·랫트 조직에서 히스톤 H3의 Lys18 아세틸화를 검출. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. -20°C 보관, 방부제 없음.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:800 |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Peptide Array (Array) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic acetylated peptide corresponding to residues surrounding Lys18 of human histone H3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 27 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977245 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other acetylated histones.
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells.
H3, along with four core histone proteins, binds to DNA forming the structure of the nucleosome.
Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability.
Post-translational modifications of histones, such as methylation, acetylation, and phosphorylation, regulate chromatin structure and transcription factor binding.
The N-terminal tail of histone H3 can undergo these modifications, influencing multiple cellular processes.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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(이미지: PA5-17801_H3K18ac_P68431-1_Rabbit.svg, PA5-17801_H3K18ac_Q71DI3-1_Rabbit.svg, PA5-17801_H3K18ac_P68431-1_Rabbit_PDP.jpeg, PA5-17801_H3K18ac_Q71DI3-1_Rabbit_PDP.jpeg)
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