Thermo Fisher Scientific Phospho-PDPK1 (Ser241) Polyclonal Antibody
PDK1의 Ser241 인산화 상태를 검출하는 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunoprecipitation (IP)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer241 of human PDK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 110 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984296 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases and activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB/Akt) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to activation of glycogen synthase and stimulation of glycogen synthesis. Given PDPK1’s role in insulin-induced glycogen synthesis and PKC activation, it is an important target for metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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