Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody
Tyrosine Hydroxylase의 Ser40 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 Immunocytochemistry에 적합. 인간 및 랫트 반응성. 항원 친화 크로마토그래피 정제. -20°C 보관, 방부제 없음.
- 카탈로그번호
- PA517799
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:200–1:400
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to the sequence surrounding pSer40 of human tyrosine hydroxylase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977526 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters—dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to enable enzymatic activity.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, sharing identical catalytic domains but differing in their N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.
TH’s role in catecholamine synthesis suggests a correlation with several neuropathogenic diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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