Thermo Fisher Scientific PSMC4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total PSMC4.

Target Information

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator.

• The 20S core consists of four rings of 28 non-identical subunits (two rings of 7 alpha subunits and two rings of 7 beta subunits).
• The 19S regulator includes a base (6 ATPase and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits).
  Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
  A modified form, the immunoproteasome, processes class I MHC peptides.
  The PSMC4 gene encodes one of the ATPase subunits, part of the AAA family of ATPases with chaperone-like activity.
  This subunit interacts with an orphan nuclear hormone receptor and gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.