Thermo Fisher Scientific TCOF1 Polyclonal Antibody
TCOF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. Human 및 Rat 반응성. 고순도 Affinity chromatography 정제, 액상 형태로 안정적 보관 가능.
- 카탈로그번호
- PA5102621
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TCOF1 (Accession Q13428), corresponding to amino acid residues G35–S85 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852018 |
Product Specific Information
Antibody detects endogenous levels of total TCOF1.
Target Information
Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene.
Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolar-cytoplasmic transport.
The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain.
Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development.
Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures, and cleft palate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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