Thermo Fisher Scientific CamK4 Polyclonal Antibody
CaMK4 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 시료에 반응합니다. Western blot과 Immunoprecipitation에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:5,000–1:15,000 |
| Immunoprecipitation (IP) | 3–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 350 and 400 of human Calcium/Calmodulin-dependent Protein Kinase IV |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is involved in transcriptional regulation in lymphocytes, neurons, and male germ cells.
The nuclear localization of this protein supports its role in mediating calcium-dependent gene expression. CaMKIV is abundant in testis, T-cells, and neurons, and plays an important role in synaptic plasticity and calcium signaling, potentially affecting NFAT activation.
In testes, CaMKIV is expressed in germ cells and associated with chromatin, suggesting a role in chromatin remodeling during spermatid nuclear condensation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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