Thermo Fisher Scientific Phospho-ITGB1 (Tyr783) Polyclonal Antibody
Integrin beta 1 인산화 Tyr783을 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 고순도 액상 형태, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human ITGB1 (Accession P05556), corresponding to amino acid residues around phosphorylated Tyr783 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817494 |
Product Specific Information
Antibody detects endogenous levels of Integrin beta 1 only when phosphorylated at Tyr783.
Target Information
ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha chains (alpha1–alpha6, CDa–f), determining the binding properties of beta1 (VLA) integrins.
ITGB1 functions as a cell adhesion molecule on platelets and as a component of protein complexes binding to extracellular matrix proteins. Decreased ITGB1 expression correlates with tumor cell multidrug resistance. It is up-regulated in leukocytes during emigration and migration, regulating immune cell trafficking.
ITGB1 also contributes to tissue damage and inflammatory bowel disease symptoms. Through ITGB1-dependent mechanisms, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1β.
Two major forms, beta1A and beta1D, differ by 13 amino acids and show tissue-specific distribution: beta1A in most tissues, beta1D in cardiac and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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