Thermo Fisher Scientific CHRM3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human muscarinic receptor M3. Validated for IHC (paraffin) at 10 µg/mL. Recognizes smooth muscle and glandular tissues. Recommended antigen retrieval with sodium citrate buffer (pH 6.0). For research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide: 3rd cytoplasmic domain of human muscarinic receptor M3, conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | <0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2080081 |
Product Specific Information
- Predicted to react with mouse based on sequence homology.
- Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for paraffin sections.
- Suggested positive control for IHC: brain, cortex.
- Rabbit anti-human muscarinic receptor M3 antibody detects the muscarinic receptor M3, a G protein-coupled receptor for acetylcholine expressed in smooth muscle and glandular tissues.
Target Information
The muscarinic cholinergic receptors belong to a family of G protein-coupled receptors. Their functional diversity arises from acetylcholine binding, leading to cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors modulate many acetylcholine effects in the central and peripheral nervous systems. The muscarinic cholinergic receptor 3 (CHRM3) regulates smooth muscle contraction and stimulates glandular secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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