Thermo Fisher Scientific DNMT3B Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-884 detects DNA methyltransferase 3 from human and mouse tissues and cells as well as recombinant human Dnmt3.
This antibody has been used to detect both recombinant and endogenous DNMT3b and recombinant DNMT3a.
PA1-884 has been successfully used in Immunohistochemistry (paraffin) and Western blot procedures.
By Western blot, this antibody detects DNMT3 from P19 nuclear extracts.

The PA1-884 immunogen is a synthetic peptide corresponding to residues 1–14 of mouse DNMT3b.
This sequence is 79% conserved between human and mouse.
PA1-884 immunizing peptide (Cat. # PEP-117) is available for use in neutralization and control experiments.

Target Information

CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation.
DNA methylation is required for mammalian development.
This gene encodes a DNA methyltransferase that functions in de novo methylation.
The protein localizes primarily to the nucleus and its expression is developmentally regulated.
Mutations in this gene cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Six alternatively spliced transcript variants have been described, with full-length sequences of variants 4 and 5 not determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.