Thermo Fisher Scientific DNMT3B Polyclonal Antibody
DNMT3B 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunohistochemistry(Paraffin)에서 사용 가능. 인간 및 생쥐 시료 반응성. 고순도 항원 친화 크로마토그래피 정제. 연구용 전용.
- 카탈로그번호
- PA1884
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2.0 µg/mL | View 10 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues M(1)K G D S R H L N E E E G A(14) C of mouse DNMT3b |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2277463 |
Product Specific Information
PA1-884 detects DNA methyltransferase 3 from human and mouse tissues and cells as well as recombinant human Dnmt3.
This antibody has been used to detect both recombinant and endogenous DNMT3b and recombinant DNMT3a.
PA1-884 has been successfully used in Immunohistochemistry (paraffin) and Western blot procedures.
By Western blot, this antibody detects DNMT3 from P19 nuclear extracts.
The PA1-884 immunogen is a synthetic peptide corresponding to residues 1–14 of mouse DNMT3b.
This sequence is 79% conserved between human and mouse.
PA1-884 immunizing peptide (Cat. # PEP-117) is available for use in neutralization and control experiments.
Target Information
CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation.
DNA methylation is required for mammalian development.
This gene encodes a DNA methyltransferase that functions in de novo methylation.
The protein localizes primarily to the nucleus and its expression is developmentally regulated.
Mutations in this gene cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Six alternatively spliced transcript variants have been described, with full-length sequences of variants 4 and 5 not determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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