Thermo Fisher Scientific Phospo-Tau (Thr217) Recombinant Rabbit Monoclonal Antibody (HL1276)

Applications

• Western Blot (WB): Assay-dependent
• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Store as concentrated solution.
• Centrifuge briefly prior to opening vial.
• This antibody can recognize both the phosphorylated and unphosphorylated target.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. Its primary function is to promote tubulin polymerization and stabilize microtubules.
The C-terminus binds to axonal microtubules, while the N-terminus binds neural plasma membrane components, suggesting a linker role between both.
Axonal polarity is influenced by TAU/MAPT localization within neurons.
Short isoforms provide cytoskeletal plasticity, while longer isoforms contribute to stabilization.
Hyper-phosphorylated Tau is the main component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease (AD).
Excessive phosphorylation disrupts microtubule binding, leading to neuronal degeneration in AD.
Several kinases, including GSK-3β, PKA, cdk5, and casein kinase II, phosphorylate Tau.
Hyper-phosphorylated Tau is also found in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.