Thermo Fisher Scientific CD206 (MMR) Monoclonal Antibody (19.2), Brilliant Ultra Violet 805, eBioscience

Thermo Fisher Scientific CD206 (MMR) Monoclonal Antibody (19.2), Brilliant Ultra Violet 805, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.25 µg)/test

Product Specifications

Additional Formats Available

• Alexa Fluor 488
• Alexa Fluor 700
• APC
• Brilliant Violet 421
• Brilliant Violet 711
• eFluor 450
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

This 19.2 monoclonal antibody reacts with human CD206, also known as macrophage mannose receptor (MMR). CD206 is expressed on macrophages and dendritic cells, and also on non-immune cells such as hepatic and lymphatic epithelia and kidney mesangial cells. It binds glycoproteins terminating in D-mannose, L-fucose, or N-acetylglucosamine, and participates in antigen processing, presentation, and phagocytosis of pathogens like Candida albicans, Leishmania, and Mycobacterium tuberculosis.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted and tested by flow cytometry using human peripheral blood cells. Recommended use: 5 µL (0.25 µg) per test.

Brilliant Ultra Violet™ 805 (BUV805) is a tandem dye emitting at 797 nm, for use on UV laser-equipped cytometers (355 nm). Ensure instrument compatibility.

Staining Buffer Recommendation:
When using multiple polymer dye-conjugated antibodies, use Super Bright Complete Staining Buffer (#SB-4401-42) or Brilliant Stain Buffer™ (#00-4409-75) to minimize non-specific interactions.

Light Sensitivity: Protect vial and samples from light.
Fixation: Compatible with IC Fixation Buffer (#00-8222-49) or 1-step Fix/Lyse Solution (#00-5333-54) for up to 3 days at 4°C in the dark.
Methanol Compatibility: Suitable for short-term methanol-based fixation (<1 hour).

Excitation: 355 nm
Emission: 797 nm
Laser: Ultraviolet Laser

BRILLIANT ULTRA VIOLET™ is a trademark or registered trademark of Becton, Dickinson and Company or its affiliates, used under license. Powered by Sirigen.

Target Information

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to pattern recognition receptors. It is mainly expressed in tissue macrophages, dendritic cells, endothelial cells, and sperm cells. CD206 plays roles in innate and adaptive immune responses, and mediates uptake of modified lipoproteins, AGEs, and amyloid β-protein. Dysregulation is implicated in atherosclerosis, Alzheimer’s disease, leprosy, and Gaucher’s disease.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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