Thermo Fisher Scientific TSLP Receptor Polyclonal Antibody
마우스 TSLP 수용체를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 2–8°C 보관, 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 21 amino acid peptide from near the center of mouse TSLP receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157042 |
Product Specific Information
- Suggested positive control: mouse heart tissue lysate
- PA5-20380 can be used with blocking peptide PEP-0497
Target Information
Thymic stromal lymphopoietin (TSLP) is a key factor that drives dendritic cell maturation and activation. It plays roles in:
- Positive selection of regulatory T cells
- Maintenance of peripheral CD4+ T cell homeostasis
- Induction of CD4+ T cell-mediated allergic reactions
TSLP also supports the growth and differentiation of fetal liver and adult B cell progenitors to the IgM-positive stage.
Its receptor, TSLP-R, binds TSLP with low affinity in transfected cells, but co-transfection with IL-7R-alpha results in high-affinity binding and formation of a functional heteromeric complex.
This receptor complex requires STAT5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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