Thermo Fisher Scientific ALK Monoclonal Antibody (OTI6E11), TrueMAB
인간 ALK 단백질(aa 1300-1620)에 특이적인 Mouse monoclonal antibody. Western blot에 적합하며, 뇌 발달 및 종양 관련 연구에 유용. 동결건조형으로 제공되며, 재구성 후 1 mg/mL 농도. PBS buffer(8% trehalose) 내 보존, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often result in fusion genes such as NPM-ALK, which exhibit oncogenic properties.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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