Thermo Fisher Scientific NFkB p50/p105 Polyclonal Antibody
NFkB p50/p105 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA, IP 등 다양한 응용에 적합. 고순도 Affinity Chromatography 정제 및 안정적인 PBS/glycerol 저장. 세포 성장, 염증, 아포토시스 연구용.
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Thermo Fisher Scientific NFkB p50/p105 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 740–964 of NFKB1 (NP_001158884.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913683 |
Product Specific Information
Positive test controls include Raji cells.
Localization: Cytoplasm, Nucleus
Immunogen sequence:
AAGADPLVEN FEPLYDLDDS WENAGEDEGV VPGTTPLDMA TSWQVFDILN GKPYEPEFTS DDLLAQGDMK QLAEDVKLQL YKLLEIPDPD KNWATLAQKL GLGILNNAFR LSPAPSKTLM DNYEVSGGTV RELVEALRQM GYTEAIEVIQ AASSPVKTTS QAHSLPLSPA STRQQIDELR DSDSVCDSGV ETSFRKLSFT ESLTSGASLL TLNKMPHDYG QEGPL
Target Information
NF-κB is a nuclear transcription factor activated by various stimuli such as cytokines, UV radiation, stress, injury, and microbial products. It regulates cellular processes including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa subunit of NF-κB, is synthesized as a p105 precursor with an N-terminal RHD region containing nuclear localization, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homo- or heterodimers (with p65) to create functional NF-κB complexes, directing nuclear translocation and DNA binding.
NF-κB has been implicated in AIDS, cancer metastasis, and rheumatoid arthritis.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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