Thermo Fisher Scientific Placental Alkaline Phosphatase Monoclonal Antibody (8B6), Biotin, eBioscience
인간 PLAP(Placental Alkaline Phosphatase)을 인식하는 8B6 단클론 항체로, Biotin으로 표지되어 있습니다. IHC(P), IHC(F), ELISA에 사용 가능하며, 인간 생식세포 종양 및 줄기세포 연구에 유용합니다. 0.5 mg/mL 농도의 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 20 µg/mL |
| Immunohistochemistry (Frozen) (IHC-F) | 20 µg/mL |
| ELISA | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8B6 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572845 |
Additional Formats
Product Specific Information
The monoclonal antibody 8B6 recognizes human Placental Alkaline Phosphatase (PLAP), a 130 kDa enzyme expressed by placental syncytiotrophoblastoid cells. PLAP exhibits distinct enzyme kinetics compared to other phosphatases and is localized both on the plasma membrane and in the cytoplasm. Expression is found in several germ line cancers such as ovarian and testicular tumors, as well as in human embryonic stem cells and bone marrow-derived mesenchymal stromal cells.
This antibody reacts with both the Regan and Nagao isozymes.
Applications Reported: Suitable for immunohistochemical staining of frozen (IHC-F) and formalin-fixed paraffin-embedded (IHC-P) tissue, and ELISA.
Applications Tested: Tested on FFPE human placenta with trypsin digestion. Recommended usage ≤ 20 µg/mL. Optimal dilution should be determined by the user.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Placental Alkaline Phosphatase (PLAP) plays a role in regulating inflammatory disease processes. There are four related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney types. PLAP, a membrane-bound isoenzyme (Regan and Nagao type), is expressed in the placenta during the third trimester of gestation and is useful in identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors express epithelial membrane antigen (EMA). PLAP may contribute to matrix mineralization; however, mice lacking this enzyme develop normal skeletons. Mutations in PLAP are linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects, with severity depending on the specific mutation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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