Thermo Fisher Scientific IRF3 Monoclonal Antibody (OTI2G3), TrueMAB
인간 IRF3 단백질을 인식하는 Mouse IgG2a 단클론 항체로, WB, IHC, ICC/IF에 사용 가능. 동결건조 형태로 제공되며, PBS + trehalose buffer에 보관. 면역반응 연구 및 IFN 관련 신호전달 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G3 |
| Immunogen | Full-length human IRF3 protein expressed in 293T cells transfected with human IRF3 expression vector |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses.
It plays a critical role in innate immunity against DNA and RNA viruses by regulating transcription of IFN-alpha, IFN-beta, and interferon-stimulated genes (ISG).
IRF3 is activated through phosphorylation by IKBKE and TBK1 kinases, leading to dimerization, nuclear translocation, and complex formation with CREB-binding protein (DRAF1), which drives transcription of IFN and ISG genes.
Mutations in IRF3 can cause acute infection-induced encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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