Thermo Fisher Scientific CD2 Monoclonal Antibody (LT2)

Applications

Product Specifications

Additional Formats

• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD2, a 50 kDa glycoprotein present on human peripheral blood T lymphocytes and NK cells. It is also expressed by all thymocytes.

Target Information

CD2 (LFA-2) is a monomeric surface antigen (MW 45–58 kDa) of the human T-lymphocyte lineage, expressed on nearly all peripheral blood T cells and most thymocytes, as well as some NK cells. It is absent on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, suggesting CD2 functions as or is associated with the erythrocyte receptor.
CD2 interacts with CD58 to stabilize adhesion between T cells and antigen-presenting cells. Although the CD2–CD58 affinity is low in solution, it is enhanced at the cell-cell interface for tight adhesion. T cell activation increases CD2 expression and mobility, facilitating contact and fixation of CD2–CD58 complexes at intercellular junctions.
CD2 deficiency is associated with reduced intestinal inflammation and susceptibility to infection. Related diseases include penile squamous cell carcinoma and immune deficiency due to thymus absence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.