Thermo Fisher Scientific DMP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein belonging to the small integrin-binding ligand N-linked glycoprotein family. It plays a critical role in the mineralization of bone and dentin and is expressed in various bone and tooth cells.
This protein contains multiple acidic domains, phosphorylation sites, an Arg-Gly-Asp (RGD) cell attachment sequence, and a DNA-binding domain. In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. Upon maturation, it becomes phosphorylated and relocates to the extracellular matrix, where it orchestrates mineralized matrix formation.
Mutations in the DMP1 gene cause autosomal recessive hypophosphatemia, leading to rickets and osteomalacia. The gene structure is conserved among mammals, and two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.