Thermo Fisher Scientific CNGB3 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 2–4 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.

Target Information

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as a second messenger. This protein can be activated by cGMP, leading to opening of the cation channel and depolarization of rod photoreceptors. It induces flickering channel gating, weakens outward rectification in the presence of extracellular calcium, increases sensitivity for L-cis diltiazem, and enhances cAMP efficiency of the channel when coexpressed with CNGA3. It is essential for the generation of light-evoked electrical responses in the red-, green-, and blue-sensitive cones.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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