Thermo Fisher Scientific Phospho-LIMK2 (Thr505) Polyclonal Antibody
Phospho-LIMK2 (Thr505) 항체로 인간, 생쥐, 랫트 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human LIMK2 around the phosphorylation site of Threonine 505 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553646 |
Product Specific Information
This antibody detects endogenous LIMK2 protein at a molecular weight of approximately 72 kDa.
Purity is greater than 95% as determined by SDS-PAGE.
Target Information
LIMK2 is a serine/threonine kinase involved in regulating actin cytoskeletal dynamics through phosphorylation of cofilin. It plays roles in brain development and cytoskeletal reorganization. LIMK2, along with LIMK1, contains two N-terminal LIM motifs and a C-terminal kinase domain. The protein is phosphorylated and activated by ROCK, a downstream effector of Rho, leading to inhibition of cofilin-mediated actin depolymerization. Multiple transcript variants encoding different isoforms of LIMK2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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