Thermo Fisher Scientific Phospho-MEK3 (Ser189) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous protein at a molecular weight of approximately 39 kDa.
Purity is >95% by SDS-PAGE.

Target Information

MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and is necessary for the expression of the glucose transporter. It phosphorylates and activates MAPK14/p38-MAPK. MEK3 can be activated by insulin and is required for glucose transporter expression. Expression of the RAS oncogene results in accumulation of the active form of MEK3, leading to constitutive activation of MAPK14 and oncogenic transformation of primary cells. Inhibition of this kinase is involved in the pathogenesis of Yersinia pseudotuberculosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.